Article
[Evidence based prevention (EBP): evidence-based approach to prevention of lung cancer by application of cytochrome 2E1 polymorphism].
Journal of UOEH - 1 Dec 2002
Oyama Tsunehiro, Kawamoto Toshihiro, Matsumoto Akiko, Isse Toyohi, Ozaki Shinichi, Yasumoto Kosei
Abstract excerpt
Most of chemical carcinogens are metabolized and activated in vivo by phase I enzymes including the microsomal cytochromes P450 (CYP) and epoxide hydroxylases. The carcinogens and their metabolites are detoxified by the phase II enzymes that include various transferases such as glutathion-S-transferases (GST). Some studies have demonstrated the association of the polymorphisms in CYP2E1 genes with the...
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