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Article

Significantly high levels of ultraviolet-specific mutations in the smoothened gene in basal cell carcinomas from DNA repair-deficient xeroderma pigmentosum patients.

Cancer research - 15 Dec 2002

Couvé-Privat Sophie, Bouadjar Bakar, Avril Marie Françoise, Sarasin Alain, Daya-Grosjean Leela

Abstract excerpt

The Sonic hedgehog (SHH) pathway is implicated in the etiology of the most common human cancer in Caucasians, the basal cell carcinoma (BCC). Mutations in the receptor of SHH, the patched gene, have been characterized in sporadic BCCs as well as those from patients with the rare genetic syndromes...

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Share to Carcinoma, Basal Cell
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Share to Receptors, Cell Surface

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Receptors, G-Protein-Coupled

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Source

Identifiers

PMID: 12499255

Genes

SHH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12499255-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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