Article
Critical role for GALR1 galanin receptor in galanin regulation of neuroendocrine function and seizure activity.
Brain research. Molecular brain research - 15 Nov 2002
Jacoby Arie Steven, Hort Yvonne Janet, Constantinescu George, Shine John, Iismaa Tiina Pauline
Abstract excerpt
The GALR1 galanin receptor is expressed at high levels within the central nervous system. To determine which specific actions of galanin are mediated by GALR1, we have developed mice with an insertional inactivating mutation within the gene encoding GALR1 (Galr1). Homozygous Galr1-/- mice are viable and capable of breeding. They exhibit no significant difference in growth rate relative to Galr1+/+ controls but...
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