Article
In Saccharomyces cerevisiae, ATP2 mRNA sorting to the vicinity of mitochondria is essential for respiratory function.
The EMBO journal - 16 Dec 2002
Margeot Antoine, Blugeon Corinne, Sylvestre Julien, Vialette Stéphane, Jacq Claude, Corral-Debrinski Marisol
Abstract excerpt
We recently demonstrated that polysome-associated mRNAs that co-isolate with mitochondria encode a subset of mitochondrial proteins, and that the 3' UTRs of these transcripts are essential for their localization to the vicinity of the organelle. To address the question of the involvement of the mRNA targeting process in mitochondrial biogenesis, we studied the role of ATP2 3' UTR. An altered ATP2 allele in which...
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