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Article

Affinities of the nucleocapsid protein for variants of SL3 RNA in HIV-1.

Biochemistry - 24 Dec 2002

Paoletti Andrew C, Shubsda Michael F, Hudson Bruce S, Borer Philip N

Abstract excerpt

Efficient packaging of genomic RNA into new HIV-1 virus particles requires that nucleocapsid domains of precursor proteins bind the SL3 tetraloop (G317-G-A-G320) from the 5'-untranslated region. This paper presents the affinities of 35 RNA variants of SL3 for the mature 55mer NC protein, as measured by fluorescence quenching of tryptophan-37 in the protein by nucleobases. The 1:1 complexes that form in 0.2 M NaCl...

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Share to Base Pair Mismatch
Share to Capsid
Share to Capsid Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to gag Gene Products, Human Immunodeficiency Virus

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Source

Identifiers

PMID: 12484783
DOI: 10.1021/bi026307n

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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