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Article

Critical comparison of molecular genotyping methods for detection of drug-resistant Plasmodium falciparum.

Transactions of the Royal Society of Tropical Medicine and Hygiene - 1 Jan 2000

Ranford-Cartwright L C, Johnston K L, Abdel-Muhsin A M, Khan B K, Babiker H A

Abstract excerpt

We have critically evaluated 3 techniques for the detection of mutations conferring drug resistance of Plasmodium falciparum, using samples containing known numbers of well-characterized parasites and artificial mixtures of these parasites at known proportions. We compared the sensitivity and specificity of mutation-specific polymerase chain reaction (MS-PCR), polymerase chain reaction followed by restriction...

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PMID: 12474492
DOI: 10.1016/s0035-9203(02)90446-3

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