Article
The transcobalamin codon 259 polymorphism influences the risk of human spontaneous abortion.
Human reproduction (Oxford, England) - 1 Dec 2002
Zetterberg H, Regland B, Palmér M, Rymo L, Zafiropoulos A, Arvanitis D A, Spandidos D A, Blennow K
Abstract excerpt
BACKGROUND: The remethylation cycle of methionine is folate and vitamin B(12) (cobalamin) dependent and appears to be crucial for embryonic development, probably through effects on synthesis of DNA, proteins and polyamines. Transcobalamin (TC) transports vitamin B(12) to the tissues. The objective of the present investigation was to explore the putative association between the major TC genetic polymorphism...
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