Article
A polymorphism in the MTHFD1 gene increases a mother's risk of having an unexplained second trimester pregnancy loss.
Molecular human reproduction - 1 Jul 2005
Parle-McDermott Anne, Pangilinan Faith, Mills James L, Signore Caroline C, Molloy Anne M, Cotter Amanda, Conley Mary, Cox Christopher, Kirke Peadar N, Scott John M, Brody Lawrence C
Abstract excerpt
Low maternal folate or vitamin B12 status has been implicated in numerous pregnancy complications including spontaneous abortion. The primary aim of this study was to test a polymorphism within the trifunctional folate enzyme MTHFD1 (5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase, 10-formyltetrahydrofolate synthetase) for an association with a mother's risk of having an...
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