Article
Myosin I is required for hypha formation in Candida albicans.
Eukaryotic cell - 1 Apr 2002
Oberholzer U, Marcil A, Leberer E, Thomas D Y, Whiteway M
Abstract excerpt
The pathogenic yeast Candida albicans can undergo a dramatic change in morphology from round yeast cells to long filamentous cells called hyphae. We have cloned the CaMYO5 gene encoding the only myosin I in C. albicans. A strain with a deletion of both copies of CaMYO5 is viable but cannot form hyphae under all hypha-inducing conditions tested. This mutant exhibits a higher frequency of random budding and a...
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