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Article

Mutations of polymerase, precore and core promoter gene in hepatitis B virus during 5-year lamivudine therapy.

Journal of hepatology - 1 Dec 2002

Suzuki Fumitaka, Suzuki Yoshiyuki, Tsubota Akihito, Akuta Norio, Someya Takashi, Kobayashi Masahiro, Saitoh Satoshi, Arase Yasuji, Ikeda Kenji, Kumada Hiromitsu

Abstract excerpt

BACKGROUND/AIMS: The effects of long-term lamivudine therapy on changes in polymerase and precore/core promoter mutations are unknown. The aim of this study was to determine the changes in these regions in patients with chronic hepatitis B virus (HBV) infection treated with lamivudine for 5 years. METHODS: Serum samples obtained from 16 patients at the beginning of and during therapy were polymerase chain...

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Identifiers

PMID: 12445424
DOI: 10.1016/s0168-8278(02)00281-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutations of polymerase, precore and core promoter gene in hepatitis B virus during 5-year lamivudine therapy.PMID 12445424Read ↗

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