Article
Host genetic profiles predict virological and immunological control of HIV-1 infection in adolescents.
AIDS (London, England) - 22 Nov 2002
Tang Jianming, Wilson Craig M, Meleth Shreelatha, Myracle Angela, Lobashevsky Elena, Mulligan Mark J, Douglas Steven D, Korber Bette, Vermund Sten H, Kaslow Richard A
Abstract excerpt
OBJECTIVE: To evaluate the correlation between host genetic profiles and virological and immunological outcomes among HIV-1-seropositive participants from the Reaching for Excellence in Adolescent Care and Health (REACH) cohort. METHODS: HLA class I and chemokine coreceptor (CCR) alleles and haplotypes were resolved in 227 HIV-1-seropositive adolescents (ages 13-18 years; 75% females; 71% African-Americans) and...
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