Article
The pathogenesis of inflammatory bowel disease: translational implications for clinicians.
Current gastroenterology reports - 1 Dec 2002
Abreu Maria T
Abstract excerpt
Research in the pathogenesis of inflammatory bowel disease (IBD) has dramatically broadened our understanding of these complex disorders. These clinical manifestations result from a dysregulated immune response in the presence of luminal bacteria. Recent identification of mutations in the NOD2 gene, a protein involved in the sensing of bacteria, offers genetic support for the model of perturbed host-microbial...
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