Article
Intraclonal diversity in a Sezary syndrome with a differential response to 2-deoxycoformycin of the two lymphoma cell populations.
British journal of haematology - 1 Dec 2002
Granjo Elisa, Lima Margarida, Lopes José Manuel, Cunha Nória, Teixeira Maria Dos Anjos, Santos Filipe, Candeias Jorge, Resende Carlos, Santos Ana Helena, Balanzategui Ana, Orfão Alberto, Matutes Estella
Abstract excerpt
We report a case of Sezary syndrome with two abnormal CD4+ T-cell populations detected in the peripheral blood by flow cytometry immunophenotyping and DNA cell content, suggesting a biclonal T-cell lymphoproliferative disorder. Despite these findings, molecular analysis of the T-cell receptor genes was consistent with a monoclonal T-cell proliferation, supporting the existence of intraclonal diversity rather than...
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