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Article

The apical stem-loop of the hepatitis B virus encapsidation signal folds into a stable tri-loop with two underlying pyrimidine bulges.

Nucleic acids research - 1 Nov 2002

Flodell Sara, Schleucher Jürgen, Cromsigt Jenny, Ippel Hans, Kidd-Ljunggren Karin, Wijmenga Sybren

Abstract excerpt

Reverse transcription of hepatitis B virus (HBV) pregenomic RNA is essential for virus replication. In the first step of this process, HBV reverse transcriptase binds to the highly conserved encapsidation signal, epsilon (epsilon), situated near the 5' end of the pregenome. epsilon has been predicted to form a bulged stem-loop with the apical stem capped by a hexa- loop. After the initial binding to this apical...

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Identifiers

PMID: 12409471
DOI: 10.1093/nar/gkf603
PMCID: PMC135823

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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