Article
Rare RHCE phenotypes in black individuals of Afro-Caribbean origin: identification and transfusion safety.
Blood - 1 Dec 2002
Noizat-Pirenne France, Lee Ketty, Pennec Pierre-Yves Le, Simon Philippe, Kazup Philippe, Bachir Dora, Rouzaud Anne-Marie, Roussel Michele, Juszczak Geneviève, Ménanteau Cècile, Rouger Philippe, Kotb Rami, Cartron Jean-Pierre, Ansart-Pirenne Hélène
Abstract excerpt
The molecular backgrounds of variants encountered in Afro-Caribbean black individuals and associated with the production of clinically significant antibodies against high-incidence antigens (anti-RH18, anti-RH34) and against Rhe epitopes were determined. We showed that RH:-18 phenotypes are produced by 3 distinct RHCE alleles: ceEK carrying 48G>C (exon 1), 712A>G, 787A>G, 800T>A (exon 5); ceBI carrying 48G>C...
Topics
- Alleles
- Anemia, Sickle Cell
- Black People
- Blood Grouping and Crossmatching
- Blood Transfusion
- Caribbean Region
- Erythrocytes
- Female
- Genetic Variation
- Glycoproteins
- Humans
- Isoantibodies
- Isoantigens