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Hypoxia reduces expression and function of system A amino acid transporters in cultured term human trophoblasts

1 Feb 2003

Abstract excerpt

We tested the hypothesis that hypoxia diminishes the expression and transport of neutral amino acids by system A in full-term human trophoblasts. Cytotrophoblasts from normal human placentas were cultured in standard conditions of 20% O(2) or in 1% and 3% O(2) for 24 h before assay. Neutral amino acid transport for systems A, ASC, and L was assayed at 24 and 72 h by the cluster-tray technique. Hypoxia during the...

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PMID: 12388062
DOI: 10.1152/ajpcell.00253.2002

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