Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Full-Length Adiponectin Attenuates Insulin Signaling and Inhibits Insulin-Stimulated Amino Acid Transport in Human Primary Trophoblast Cells

11 Feb 2010

Abstract excerpt

OBJECTIVE: Maternal adiponectin levels are reduced and placental nutrient transporters are upregulated in obesity and gestational diabetes mellitus; however, the effects of adiponectin on placental function are unknown. We hypothesized that adiponectin regulates placental amino acid transport. RESEARCH DESIGN AND METHODS: Human primary trophoblast cells were cultured and incubated with globular adiponectin (gAd)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipokines, Inflammation, and Metabolic Diseases
Share to Gestational Diabetes Research and Management
Share to Pregnancy and preeclampsia studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20150288
DOI: 10.2337/db09-0824

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Full-Length Adiponectin Attenuates Insulin Signaling and Inhibits Insulin-Stimulated Amino Acid Transport in Human Primary Trophoblast CellsPMID 20150288Read ↗

Regulation of placental amino acid transport in health and diseaseSemantic proximity Read ↗

TNF-αstimulates System A amino acid transport in primary human trophoblast cells mediated by p38 MAPK signalingSemantic proximity Read ↗

GDM-Induced Macrosomia Is Reversed by Cav-1 via AMPK-Mediated Fatty Acid Transport and GLUT1-Mediated Glucose Transport in PlacentaSemantic proximity Read ↗

Vasoactive Intestinal Peptide induces glucose and neutral amino acid uptake through mTOR signalling in human cytotrophoblast cellsSemantic proximity Read ↗

GLUT1 exacerbates trophoblast ferroptosis by modulating AMPK/ACC mediated lipid metabolism and promotes gestational diabetes mellitus associated fetal growth restrictionSemantic proximity Read ↗

IL-6 stimulates system A amino acid transporter activity in trophoblast cells through STAT3 and increased expression of SNAT2Semantic proximity Read ↗

Mammalian target of rapamycin signalling modulates amino acid uptake by regulating transporter cell surface abundance in primary human trophoblast cellsSemantic proximity Read ↗

AMPK Knockdown in Placental Trophoblast Cells Results in Altered Morphology and FunctionSemantic proximity Read ↗

Hormonal regulation of glucose and system A amino acid transport in first trimester placental villous fragmentsSemantic proximity Read ↗

AMPK Signaling Regulates Mitophagy and Mitochondrial ATP Production in Human Trophoblast Cell Line BeWoSemantic proximity Read ↗

Expression and functional characterisation of System L amino acid transporters in the human term placentaSemantic proximity Read ↗

Human placental uptake of glutamine and glutamate is reduced in fetal growth restrictionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.