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Article

Expression and functional characterisation of System L amino acid transporters in the human term placenta

8 Jun 2015

Abstract excerpt

BACKGROUND: System L transporters LAT1 (SLC7A5) and LAT2 (SLC7A8) mediate the uptake of large, neutral amino acids in the human placenta. Many System L substrates are essential amino acids, thus representing crucial nutrients for the growing fetus. Both LAT isoforms are expressed in the human placenta, but the relative contribution of LAT1 and LAT2 to placental System L transport and their subcellular...

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PMID: 26050671
DOI: 10.1186/s12958-015-0054-8

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