Article
Mutation screening of the muscarinic m2 and m3 receptor genes in asthmatics, outgrow subjects, and normal controls.
Annales de genetique - 1 Jan 2000
Yamamoto Toshiko, Yamashita Naomi, Kuwabara Maya, Nakano Junichi, Sugimoto Hideo, Akiyama Kazuo, Hirai Koichi, Ishii Akira, Uehara Yoshio, Ohta Ken
Abstract excerpt
Muscarinic receptors are important in the development of airway hyperresponsiveness. In some patients with asthma and in animal models of hyperreactivity, functional abnormalities in these receptors are suggested to contribute to disease. Here, we have screened for single nucleotide polymorphisms in the coding region of human muscarinic m2 and m3 receptor genes using direct fluorescence sequencing. DNA samples...
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