Alterations in telomeric repeat length in lung cancer are associated with loss of heterozygosity in p53 and Rb.

Article

Alterations in telomeric repeat length in lung cancer are associated with loss of heterozygosity in p53 and Rb.

Oncogene - 2 Mar 1995

Hiyama K, Ishioka S, Shirotani Y, Inai K, Hiyama E, Murakami I, Isobe T, Inamizu T, Yamakido M

Abstract excerpt

In the two-stage model of controlling cellular senescence in cultured human fibroblasts, retinoblastoma (Rb) and p53 proteins may be key factors regulating the mortality stage 1 mechanism. In addition, the critical loss of telomeric DNA due to the end-replication problem may result in the mortali...

Topics

Base Sequence
Chromosome Deletion
Chromosomes, Human, Pair 1
Genes, Retinoblastoma
Genes, p53
Genes, ras
Humans
Lung Neoplasms
Molecular Sequence Data
Mutation
Telomere

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