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Article

Gene perturbation and intervention in probabilistic Boolean networks.

Bioinformatics (Oxford, England) - 1 Oct 2002

Shmulevich Ilya, Dougherty Edward R, Zhang Wei

Abstract excerpt

MOTIVATION: A major objective of gene regulatory network modeling, in addition to gaining a deeper understanding of genetic regulation and control, is the development of computational tools for the identification and discovery of potential targets for therapeutic intervention in diseases such as cancer. We consider the general question of the potential effect of individual genes on the global dynamical network...

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PMID: 12376376
DOI: 10.1093/bioinformatics/18.10.1319

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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