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Article

Involvement of survival motor neuron (SMN) protein in cell death.

Human molecular genetics - 15 Oct 2002

Vyas Sheela, Béchade Catherine, Riveau Béatrice, Downward Julian, Triller Antoine

Abstract excerpt

Infantile spinal muscular atrophy (SMA) is caused by mutations in the survival motor neuron (SMN)1 gene. We investigated the role of human (h) SMN protein on cell death in PC12 and Rat-1 cells. hSMN prolonged cell survival in PC12 cells deprived of trophic support and in Rat-1 cells induced to die by activation of the proto-oncogene c-Myc, to similar magnitude as Bcl-2 or IAP-2. While hSMN was ineffective in...

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Identifiers

PMID: 12374765
DOI: 10.1093/hmg/11.22.2751

Genes

NGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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