Article
How mitochondrial damage affects cell function.
Journal of biomedical science - 1 Jan 2002
James Andrew M, Murphy Michael P
Abstract excerpt
The pathophysiology of mitochondrial DNA (mtDNA) diseases is caused by increased cell death and dysfunction due to the accumulation of mutations to mtDNA. While the disruption of oxidative phosphorylation is central to mtDNA diseases, many other factors, such as Ca(2+) dyshomeostasis, increased oxidative stress and defective turnover of mitochondrial proteins, may also contribute. The relative importance of these...
Topics
- Animals
- Calcium
- Cell Death
- Cells
- DNA, Mitochondrial
- Homeostasis
- Humans
- Mitochondria
- Mitochondrial Diseases
- Mutation
- Oxidative Stress
- Phosphorylation