Mutational Analysis of the Uukuniemi Virus ( Bunyaviridae Family) Promoter Reveals Two Elements of Functional Importance

doi:10.1128/jvi.76.21.10849-10860.2002

Article

Mutational Analysis of the Uukuniemi Virus ( Bunyaviridae Family) Promoter Reveals Two Elements of Functional Importance

4 Oct 2002

Abstract excerpt

We have performed an extensive mutational analysis of the proposed promoter region of the phlebovirus Uukuniemi (UUK), a member of the Bunyaviridae family. This was achieved by using a recently developed RNA polymerase I (Pol I)-driven reverse genetics system (R. Flick and R. F. Pettersson, J. Virol. 75:1643-1655, 2001). Chimeric cDNAs containing the coding region for the reporter chloramphenicol...

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