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A Reverse Genetics System for Zika Virus Based on a Simple Molecular Cloning Strategy

12 Jul 2018

Abstract excerpt

The Zika virus (ZIKV) has recently attracted major research interest as infection was unexpectedly associated with neurological manifestations in developing foetuses and with Guillain-Barré syndrome in infected adults. Understanding the underlying molecular mechanisms requires reverse genetic systems, which allow manipulation of infectious cDNA clones at will. In the case of flaviviruses, to which ZIKV belongs,...

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PMID: 30002313
DOI: 10.3390/v10070368

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