Article
Senescence marker protein-30 knockout mouse liver is highly susceptible to tumor necrosis factor-alpha- and Fas-mediated apoptosis.
The American journal of pathology - 1 Oct 2002
Ishigami Akihito, Fujita Toshiko, Handa Setsuko, Shirasawa Takuji, Koseki Haruhiko, Kitamura Tsuneo, Enomoto Nobuyuki, Sato Nobuhiro, Shimosawa Tatsuo, Maruyama Naoki
Abstract excerpt
Senescence marker protein-30 (SMP30) is a calcium-binding protein that decreases in an androgen-independent manner with aging. To elucidate the physiological role of this protein, we introduced a null mutation of the SMP30 gene into the germ line of mice. Despite the complete lack of SMP30 (SMP30-/-), these mutant mice were indistinguishable from their wild-type (SMP30+/+) littermates in terms of development and...
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