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Article

Evolution of supergene families associated with insecticide resistance.

Science (New York, N.Y.) - 4 Oct 2002

Ranson Hilary, Claudianos Charles, Ortelli Federica, Abgrall Christelle, Hemingway Janet, Sharakhova Maria V, Unger Maria F, Collins Frank H, Feyereisen René

Abstract excerpt

The emergence of insecticide resistance in the mosquito poses a serious threat to the efficacy of many malaria control programs. We have searched the Anopheles gambiae genome for members of the three major enzyme families- the carboxylesterases, glutathione transferases, and cytochrome P450s-that are primarily responsible for metabolic resistance to insecticides. A comparative genomic analysis with Drosophila...

Topics

Animals
Anopheles
Carboxylic Ester Hydrolases
Computational Biology
Conserved Sequence
Cytochrome P-450 Enzyme System
Drosophila melanogaster
Evolution, Molecular
Genes, Duplicate
Genes, Insect

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genome

Genomics

Glutathione Transferase

Insecticide Resistance

Multigene Family

Mutation

Phylogeny

Physical Chromosome Mapping

Source

Identifiers

PMID: 12364796
DOI: 10.1126/science.1076781

Provenance

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