Article
Molecular cloning and characterization of a novel UDP-Gal:GalNAc(alpha) peptide beta 1,3-galactosyltransferase (C1Gal-T2), an enzyme synthesizing a core 1 structure of O-glycan.
The Journal of biological chemistry - 6 Dec 2002
Kudo Takashi, Iwai Toshie, Kubota Tomomi, Iwasaki Hiroko, Takayma Yuko, Hiruma Toru, Inaba Niro, Zhang Yan, Gotoh Masanori, Togayachi Akira, Narimatsu Hisashi
Abstract excerpt
Recently, a UDP-Gal:GalNAc(alpha) peptide beta1,3-galactosyltransferase (core 1 synthase 1; C1Gal-T1) has been purified from rat liver and its complementary DNA cloned from several species. We isolated a second candidate for core 1 synthase from a Colo205 cDNA library and named it C1Gal-T2. The deduced amino acid sequence of C1Gal-T2, having 26% homology to C1Gal-T1, showed a topology typical of a type II...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.