Article
Idiopathic slow transit constipation and megacolon are not associated with neurturin mutations.
Neurogastroenterology and motility - 1 Oct 2002
Chen B, Knowles C H, Scott M, Anand P, Williams N S, Milbrandt J, Tam P K H
Abstract excerpt
Chronic idiopathic slow-transit constipation (ISTC) and idiopathic megacolon (IMC) are early-onset gastrointestinal motility disorders of unknown aetiology. The gene encoding the neurotrophic factor neurturin may be a candidate for these disorders, as neurturin-deficient mice have a similar enteric phenotype. In the present study, we tested this hypothesis. Genomic DNA from 26 cases of chronic idiopathic STC...
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