Article
Multiple endocrine neoplasia type 1 polymorphism D418D is associated with sporadic primary hyperparathyroidism.
Surgery - 1 Sept 2002
Correa Pamela, Lundgren Ewa, Rastad Jonas, åkerström Göran, Westin Gunnar, Carling Tobias
Abstract excerpt
BACKGROUND: Sporadic primary hyperparathyroidism (pHPT) occurs separately and in several hereditary disorders including multiple endocrine neoplasia type 1. Irradiation to the neck, female gender, and age are well-identified risk factors that predispose to pHPT. The multiple endocrine neoplasia type 1 gene is the most commonly deranged gene in parathyroid adenomas and contains several polymorphisms including...
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