Article
Family History Predicts Primary Hyperparathyroidism Regardless of Genetic Predisposition.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists - 1 Aug 2026
Halperin Reut, Tripto-Shkolnik Liana, Vered Iris, Klein Pinchas, Avior Galit, Milloh-Raz Hadar, Ilany Jacob, Peltz-Sinvani Naama, Cukierman-Yaffe Tali, Lasman Nir, Ben-Shmuel Sigal, Jabarin Amna, Eden-Friedman Yehudit, Goldinger Gil, Shlomai Gadi, Peshes Yaloz Naama, Tirosh Amit
Abstract excerpt
OBJECTIVES: Primary hyperparathyroidism (PHPT) has a known genetic predisposition in only 10% of cases. We aimed to identify predictors of PHPT occurrence in carriers and noncarriers of a pathogenic variant (PV) in PHPT-related genes. METHODS: A prospective study of patients who underwent genetic assessment for PHPT or suspected endocrine neoplasia syndrome. Demographics, clinical, biochemical, and genetic...
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