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Article

Pharmacokinetics of diltiazem and its metabolites in relation to CYP2D6 genotype.

Clinical pharmacology and therapeutics - 1 Sept 2002

Molden Espen, Johansen Per Wiik, Bøe Grethe Helen, Bergan Stein, Christensen Hege, Rugstad Hans Erik, Rootwelt Helge, Reubsaet Leon, Lehne Gustav

Abstract excerpt

OBJECTIVES: Recently, it was shown in vitro that the polymorphic enzyme cytochrome P450 (CYP) 2D6 mediates O-demethylation of diltiazem. The aim of this study was to compare the pharmacokinetics of diltiazem and its major metabolites in healthy human volunteers representing different CYP2D6 genotypes. METHODS: Norwegians of Caucasian origin were screened for their CYP2D6 genotype on the LightCycler (Roche...

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Identifiers

PMID: 12235455
DOI: 10.1067/mcp.2002.127396

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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