Article
ApoC-III gene polymorphisms and risk of coronary artery disease.
Journal of lipid research - 1 Sept 2002
Olivieri Oliviero, Stranieri Chiara, Bassi Antonella, Zaia Barbara, Girelli Domenico, Pizzolo Francesca, Trabetti Elisabetta, Cheng Suzanne, Grow Michael A, Pignatti Pier Franco, Corrocher Roberto
Abstract excerpt
Several polymorphisms in the apolipoprotein C-III (apoC-III) gene have been associated with hypertriglyceridemia, but the link with coronary artery disease risk is still controversial. In particular, apoC-III promoter sequence variants in the insulin responsive element (IRE), constitutively resistant to downregulation by insulin, have never been investigated in this connection. We studied a total of 800 patients,...
Topics
- Adult
- Apolipoprotein A-I
- Apolipoprotein C-III
- Apolipoproteins B
- Apolipoproteins C
- Biomarkers
- Coronary Artery Disease
- Female
- Genetic Predisposition to Disease
- Genotype
- Humans
- Insulin
- Male