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Article

Rapid screening for alpha1-antitrypsin deficiency in patients with chronic obstructive pulmonary disease using dried blood specimens.

American journal of respiratory and critical care medicine - 15 Sept 2002

Rodriguez Francisco, Jardí Rosendo, Costa Xose, Cotrina Montserrat, Galimany Roman, Vidal Rafael, Miravitlles Marc

Abstract excerpt

We describe two reliable methods for high-throughput screening of proteinase inhibitor (PI) S and PI Z alpha(1)-antitrypsin (alpha(1)-AT) deficiency alleles from dried blood spot (DBS) specimens using the LightCycler fluorimetric analyzer. The method was used to study 72 patients with chronic obstructive pulmonary disease. Results were confirmed with DNA sequencing. The alpha(1)-AT concentration in DBS was...

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Identifiers

PMID: 12231490
DOI: 10.1164/rccm.2203025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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