Article
Characterization of the promoter for the mouse alpha 3 integrin gene.
European journal of biochemistry - 1 Sept 2002
Kato Takumi, Katabami Kouji, Takatsuki Hironori, Han Seon Ae, Takeuchi Ken-Ichi, Irimura Tatsuro, Tsuji Tsutomu
Abstract excerpt
The alpha 3 beta 1 integrin is an adhesion receptor for extracellular matrix proteins including isoforms of laminin, and the changes of its expression level in various cancer cells are thought to cause their malignant phenotypes. We have cloned an approximately 4 kb DNA fragment of the 5'-flanking region of the murine alpha 3 integrin gene and analyzed its promoter activity. Transfection of MKN1 gastric carcinoma...
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