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Article

The membrane biogenesis peroxin Pex16p. Topogenesis and functional roles in peroxisomal membrane assembly.

The Journal of biological chemistry - 15 Nov 2002

Honsho Masanori, Hiroshige Takanobu, Fujiki Yukio

Abstract excerpt

Previously we isolated human PEX16 encoding 336-amino acid-long peroxin Pex16p and showed that its dysfunction was responsible for Zellweger syndrome of complementation group D (group 9). Here we have determined the membrane topology of Pex16p by differential permeabilization method: both N- and C-terminal parts are exposed to the cytosol. In the search for Pex16p topogenic sequence, basic amino acids clustered...

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Source

Identifiers

PMID: 12223482
DOI: 10.1074/jbc.M206139200

Genes

PEX12
PEX16
PEX3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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The membrane biogenesis peroxin Pex16p. Topogenesis and functional roles in peroxisomal membrane assembly.PMID 12223482Read ↗

Peroxisome biogenesis disorders: molecular basis for impaired peroxisomal membrane assembly: in metabolic functions and biogenesis of peroxisomes in health and disease.Semantic proximity Read ↗

Mutation in PEX16 is causal in the peroxisome-deficient Zellweger syndrome of complementation group D.Semantic proximity Read ↗

Functional domain mapping of peroxin Pex19p: interaction with Pex3p is essential for function and translocation.Semantic proximity Read ↗

Identification of an unusual variant peroxisome biogenesis disorder caused by mutations in the PEX16 gene.Semantic proximity Read ↗

The pathogenic peroxin Pex26p recruits the Pex1p-Pex6p AAA ATPase complexes to peroxisomes.Semantic proximity Read ↗

Pex17p of Saccharomyces cerevisiae is a novel peroxin and component of the peroxisomal protein translocation machinery.Semantic proximity Read ↗

Mutations in the peroxin Pex26p responsible for peroxisome biogenesis disorders of complementation group 8 impair its stability, peroxisomal localization, and interaction with the Pex1p x Pex6p complex.Semantic proximity Read ↗

Mitochondria and Peroxisome Crosstalk in Peroxisome Biogenesis Disorder 8A Caused by a Rare Variant in PEX16 Gene.Semantic proximity Read ↗

Functional domains and dynamic assembly of the peroxin Pex14p, the entry site of matrix proteins.Semantic proximity Read ↗

Drosophila carrying pex3 or pex16 mutations are models of Zellweger syndrome that reflect its symptoms associated with the absence of peroxisomes.Semantic proximity Read ↗

A novel aberrant splicing mutation of the PEX16 gene in two patients with Zellweger syndrome.Semantic proximity Read ↗

Peroxisomal Pex11 is a pore-forming protein homologous to TRPM channels.Semantic proximity Read ↗

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