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Article

The pathogenic peroxin Pex26p recruits the Pex1p-Pex6p AAA ATPase complexes to peroxisomes.

Nature cell biology - 1 May 2003

Matsumoto Naomi, Tamura Shigehiko, Fujiki Yukio

Abstract excerpt

Peroxisomes are ubiquitous organelles with a single membrane that contain over 50 different enzymes that catalyse various metabolic pathways, including beta-oxidation and lipid synthesis. Peroxisome biogenesis disorders (PBDs), such as Zellweger syndrome and neonatal adrenoleukodystrophy, are fatal genetic diseases that are autosomal recessive. Among the PBDs of the 12 complementation groups (CGs), 11 associated...

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Source

Identifiers

PMID: 12717447
DOI: 10.1038/ncb982

Genes

PEX26

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The pathogenic peroxin Pex26p recruits the Pex1p-Pex6p AAA ATPase complexes to peroxisomes.PMID 12717447Read ↗

Mutations in the peroxin Pex26p responsible for peroxisome biogenesis disorders of complementation group 8 impair its stability, peroxisomal localization, and interaction with the Pex1p x Pex6p complex.Semantic proximity Read ↗

Mutations in novel peroxin gene PEX26 that cause peroxisome-biogenesis disorders of complementation group 8 provide a genotype-phenotype correlation.Semantic proximity Read ↗

The PEX1 ATPase Stabilizes PEX6 and Plays Essential Roles in Peroxisome Biology.Semantic proximity Read ↗

Genomic structure and identification of 11 novel mutations of the PEX6 (peroxisome assembly factor-2) gene in patients with peroxisome biogenesis disorders.Semantic proximity Read ↗

Temperature-sensitive mutation in PEX1 moderates the phenotypes of peroxisome deficiency disorders.Semantic proximity Read ↗

Genotype-phenotype correlations in disorders of peroxisome biogenesis.Semantic proximity Read ↗

A pex1 missense mutation improves peroxisome function in a subset of Arabidopsis pex6 mutants without restoring PEX5 recyclingSemantic proximity Read ↗

The membrane biogenesis peroxin Pex16p. Topogenesis and functional roles in peroxisomal membrane assembly.Semantic proximity Read ↗

Human PEX1 is mutated in complementation group 1 of the peroxisome biogenesis disorders.Semantic proximity Read ↗

Mutation in PEX16 is causal in the peroxisome-deficient Zellweger syndrome of complementation group D.Semantic proximity Read ↗

PEX6 Mutations in Peroxisomal Biogenesis DisordersSemantic proximity Read ↗

Mutations in PEX1 are the most common cause of peroxisome biogenesis disorders.Semantic proximity Read ↗

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