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Article

Role for phospholipid interactions in the trafficking defect of Delta F508-CFTR.

Biochemistry - 17 Sept 2002

Eidelman Ofer, BarNoy Shoshana, Razin Michal, Zhang Jiang, McPhie Peter, Lee George, Huang Zhen, Sorscher Eric J, Pollard Harvey B

Abstract excerpt

Cystic fibrosis commonly occurs as a consequence of the DeltaF508 mutation in the first nucleotide binding fold domain (NBF-1) of CFTR. The mutation causes retention of the mutant CFTR molecule in the endoplasmic reticulum, and this aberrant trafficking event is believed to be due to defective interactions between the mutant NBF-1 domain and other cellular factors in the endoplasmic reticulum. Since the NBF-1...

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Source

Identifiers

PMID: 12220181
DOI: 10.1021/bi020289s

Genes

CFTR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Role for phospholipid interactions in the trafficking defect of Delta F508-CFTR.PMID 12220181Read ↗

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