Article
Polymorphisms of human CD19 gene: possible association with susceptibility to systemic lupus erythematosus in Japanese.
Genes and immunity - 1 Oct 2002
Kuroki K, Tsuchiya N, Tsao B P, Grossman J M, Fukazawa T, Hagiwara K, Kano H, Takazoe M, Iwata T, Hashimoto H, Tokunaga K
Abstract excerpt
CD19 regulates the signaling for B lymphocyte development, activation and proliferation. In mice, CD19 deficiency and overexpression were shown to result in hypogammaglobulinemia and autoantibody production, respectively. In the present study, we screened for the polymorphisms of CD19, and examined the detected polymorphisms for the association with rheumatoid arthritis (RA), Crohn's disease and systemic lupus...
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