Article
Purification and characterization of the active form of tyrosine hydroxylase from mesangial cells in culture.
Journal of cellular biochemistry - 1 Jan 2002
Arita Danielle Yuri, Di Marco Giovana Seno, Schor Nestor, Casarini Dulce Elena
Abstract excerpt
The capacity of mesangial cells (MC) to produce catecholamines (CAs) has been investigated in our laboratory. To study the CA cascade, it is necessary to examine some steps in their metabolic pathway. Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the biosynthesis of these biogenic amines (dopamine (DA), norepinephrine (NE), and epinephrine (EPI)). Since the glomerular mesangium is their target in...
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