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Regulatory subunit type I‐α of protein kinase A (<i>PRKAR1A</i>): A tumor‐suppressor gene for sporadic thyroid cancer

26 Aug 2002

Abstract excerpt

The tumor-suppressor gene encoding the cyclic AMP-dependent protein kinase A type I-alpha regulatory subunit PRKAR1A has been mapped to chromosome 17 (17q22-24) and is mutated in Carney complex, a familial neoplasia syndrome that is associated with thyroid tumors. Other genes implicated in cyclic nucleotide-dependent signaling have been investigated in thyroid tumorigenesis. We studied protein kinase A (PKA)...

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PMID: 12203783
DOI: 10.1002/gcc.10112

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