Article
Molecular mechanisms of mild and moderate hemophilia A.
Journal of thrombosis and haemostasis : JTH - 1 Mar 2003
Jacquemin M, De Maeyer M, D'Oiron R, Lavend'Homme R, Peerlinck K, Saint-Remy J-M
Abstract excerpt
Mutations responsible for mild/moderate hemophilia A were extensively characterized over the last 15 years and more than 200 mutations have been identified. However, most of the molecular mechanisms responsible for the reduced factor (F)VIII levels in patients' plasma were determined only recently. Recent progresses in the study of the FVIII molecule three-dimensional structure provided a major insight for...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.