Article
A naturally occurring mutation in the SLC21A6 gene causing impaired membrane localization of the hepatocyte uptake transporter.
The Journal of biological chemistry - 8 Nov 2002
Michalski Christoph, Cui Yunhai, Nies Anne T, Nuessler Andreas K, Neuhaus Peter, Zanger Ulrich M, Klein Kathrin, Eichelbaum Michel, Keppler Dietrich, Konig Jorg
Abstract excerpt
The organic anion transporter SLC21A6 (also known as OATP2, OATP-C, or LST-1) is involved in the hepatocellular uptake of a variety of endogenous and xenobiotic substances and drugs. We analyzed 81 human liver samples by immunoblotting and found one with a strongly reduced amount of SLC21A6 protein suggesting mutations in the SLC21A6 gene. The SLC21A6 cDNA from this sample contained five base pair changes in one...
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