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Article

Rta of the human herpesvirus 8/Kaposi sarcoma–associated herpesvirus up-regulates human interleukin-6 gene expression

1 Sept 2002

Abstract excerpt

Human herpesvirus 8 (HHV-8)/Kaposi sarcoma-associated herpesvirus (KSHV) is linked to a number of malignancies thought to be driven by cytokines, including interleukin-6 (IL-6). Rta, a transcriptional activator encoded by HHV-8/KSHV, activates the viral lytic cycle leading to the expression of several viral genes implicated in viral pathogenesis. However, the effect of HHV-8/KSHV Rta on cellular genes has not...

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Identifiers

PMID: 12176919
DOI: 10.1182/blood-2002-01-0015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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