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Article

Kaposi's sarcoma‐associated herpesviral IL‐6 and human IL‐6 open reading frames contain miRNA binding sites and are subject to cellular miRNA regulation

4 Jul 2011

Abstract excerpt

Kaposi's sarcoma-associated herpesvirus (KSHV) encodes a viral interleukin 6 (vIL-6) that mimics many activities of human IL-6 (hIL-6). Both vIL-6 and hIL-6 play important roles in stimulating the proliferation of tumours caused by KSHV. Here, we provide evidence that a miRNA pathway is involved in regulation of vIL-6 and hIL-6 expression through binding sites in their open reading frames (ORFs). We show a direct...

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PMID: 21984125
DOI: 10.1002/path.2962

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