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Article

Intracellular Signaling Mechanisms and Activities of Human Herpesvirus 8 Interleukin-6

6 Nov 2008

Abstract excerpt

Human herpesvirus 8 (HHV-8)-encoded viral interleukin-6 (vIL-6) has been implicated as a key factor in virus-associated neoplasia because of its proproliferative and survival effects and also in view of its angiogenic properties. A major difference between vIL-6 and human IL-6 (hIL-6) is that vIL-6, uniquely, is largely retained and can signal intracellularly. While vIL-6 is generally considered to be a lytic...

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PMID: 18987143
DOI: 10.1128/jvi.01517-08

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