Article
Frequent detection of human papilloma viruses in cervical dysplasia by PCR single-strand DNA-conformational polymorphism analysis.
Anticancer research - 1 Jan 2000
Nakagawa Hiroyuki, Sugano Kokichi, Fujii Takuma, Kubushiro Kaneyuki, Tsukazaki Katsumi, Nozawa Shiro
Abstract excerpt
BACKGROUND: To clarify the pathogenicity of multiple human papilloma virus (HPV) infection, we applied SSCP (single-strand DNA conformation polymorphism) analysis for cervical neoplastic lesions. MATERIALS AND METHODS: Two hundred and sixty-six cervical swab specimens from normal cervix (n=64), cervical dysplasia (n=95), carcinoma in situ (n=79) and cervical cancer (n=28), were studied by nested PCR-SSCP analysis...
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