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Article

Low incidence of paradoxical platelet activation by glycoprotein IIb/IIIa inhibitors.

Thrombosis research - 1 Apr 2002

Weber Artur-Aron, Meila Dan, Jacobs Collin, Weber Stephanie, Kelm Malte, Strauer Bodo E, Zotz Rainer B, Scharf Rüdiger E, Schrör Karsten

Abstract excerpt

The human platelet antigen-1 (HPA-1, Pl(A)) polymorphism has been proposed to influence the inhibitory actions of abciximab. Thus, we hypothesized that this polymorphism might also be the cause for paradoxical activation of platelets by GPIIb/IIIa inhibitors. The effects of abciximab (1-10 microg/ml), tirofiban (3-30 nM), or eptifibatide (0.3-3 microg/ml) on basal and ADP (3 microM)-induced CD62P externalization...

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Identifiers

PMID: 12165285
DOI: 10.1016/s0049-3848(02)00083-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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