Characterization of measles virus strains causing SSPE: a study of 11 cases.

doi:10.1080/13550280290100752

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Article

Characterization of measles virus strains causing SSPE: a study of 11 cases.

Journal of neurovirology - 1 Aug 2002

Jin L, Beard S, Hunjan R, Brown D W G, Miller E

Abstract excerpt

Eleven subacute sclerosing panencephalitis (SSPE) cases diagnosed in the UK between 1965 and 2000 were investigated. The entire or partial matrix (M), hemagglutinin (H), and nucleoprotein (N) genes of measles virus (MV) were sequenced following direct RT-PCR amplification from brain tissues. All the M genes showed the characteristic biased hypermutations and a premature termination codon was detected in 5/11 M...

Topics

Adolescent
Adult
Amino Acid Substitution
Child
Evolution, Molecular
Female
Genome, Viral
Genotype
Humans
Male
Measles virus
Molecular Sequence Data
Phylogeny
Pregnancy
Subacute Sclerosing Panencephalitis

Source

Open in PubMed

Identifiers

PMID: 12161818
DOI: 10.1080/13550280290100752

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