Article
Genetic susceptibility to keloid disease and transforming growth factor beta 2 polymorphisms.
British journal of plastic surgery - 1 Jun 2002
Bayat A, Bock O, Mrowietz U, Ollier W E R, Ferguson M W J
Abstract excerpt
Keloid disease (KD) is a benign fibroproliferative scarring condition of unknown aetiopathogenesis. There is a familial predisposition to keloid scarring. The genes involved in the pathogenesis of abnormal dermal scarring have yet to be identified. Transforming growth factor beta (TGF beta) is a family of multifunctional cytokines, which play a central role in wound healing and fibrosis. The TGF beta 2 isoform is...
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